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Sweetness Receptor Site:
The drastically increased sweetness of sucralose is due to
the structure of molecule. In the case of sucralose, the two
chlorine atoms present in the fructose portion of the molecule
lead to more hydrophobic properties on the opposite side of the
molecule (upper left), which extends over the entire outer region
of the fructose portion of the sucralose molecule.
Note: The model receptor site is this author's conception
and is based only very loosely on theory and geometry of the
molecules. It is only useful for students' initial conceptions
of the fit of a molecule into a receptor site.
Area (AH+): This area has hydrogens available to hydrogen
bond to chlorine attached to the glucose bottom portion of the
molecule.
Note: The model receptor site is this author's conception
and is based only very loosely on theory and geometry of the
molecules. It is only useful for students' initial conceptions
of the fit of a molecule into a receptor site.
Area (B -): This area has a partially negative oxygen
available to hydrogen bond to the partially positive hydrogen
of an alcohol group.
Area (X): This area is more or less perpendicular to
the other two areas interacts through hydrophobic or non-polar
properties to the fructose portion of the molecule as previously
noted.
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