The NAD+ is represented as cyan in the graphic
on the left. The alcohol is represented by the space filling
red, gray, and white atoms.
The reaction is to convert the alcohol, ethanol, into ethanal,
Reaction: CH3CH2OH + NAD+
---> CH3CH=O + NADH + H+
This is an oxidation reaction and results in the removal of
two hydrogen ions and two electrons which are added to the NAD+,
converting it to NADH and H+. This is the first reaction
in the metabolism of alcohol.
The active site of ADH has two binding regions. The coenzyme
binding site, where NAD+ binds, and the substrate
binding site, where the alcohol binds. Most of the binding site
for the NAD+ is hydrophobic as represented in green.
Three key amino acids involved in the catalytic oxidation
of alcohols to aldehydes and ketones. They are ser-48, phe 140,
and phe 93.
Alcohol Dehydrogenase - Chime
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