Deamination is also an oxidative reaction that occurs under
aerobic conditions in all tissues but especially the liver. During
oxidative deamination, an amino acid is converted into
the corresponding keto acid by the removal of the amine functional
group as ammonia and the amine functional group is replaced by
the ketone group. The ammonia eventually goes into the urea cycle.
Oxidative deamination occurs primarily on glutamic acid because
glutamic acid was the end product of many transamination reactions.
The glutamate dehydrogenase is allosterically controlled by
ATP and ADP. ATP acts as an inhibitor whereas ADP is an activator.
Link to: Transamination
and Deamination (move cursor over arrows)
Jim Hardy, Professor of Chemistry, The University of Akron.