Glucose

 

Reaction 1: Phosphate Ester Synthesis

Phosphate is added to the glucose at the C-6 position. The reaction is a phosphate ester synthesis using the alcohol on the glucose and a phosphate from ATP.

This first reaction is endothermic and thus requires energy from a coupled reaction with ATP. ATP is used by being hydrolyzed to ADP and phosphate giving off energy and the phosphate for reaction with the glucose for a net loss of ATP.

This reaction is catalyzed by hexokinase.

 Glucose-6-phosphate

Color Codes
C

H

N

O

P

S

Cl

F

 Click-hold mouse button to move structure.
Click "x" box to toggle between structures
.
 Move manually to match left window
  Spacefill / ball & stick   Optimal View - left window   Spacefill / ball & stick
Reaction Changes / ball & stick

 Alcohol to phosphate ester
  Reaction Changes / ball & stick
      

 

   Wireframe / ball & stick   Identify as glucose / ball & stick   Wireframe / ball & stick  
    MEP / ball & stick     MEP / ball & stick
    MEP (transparent) / ball & stick     MEP (transparent) / ball & stick