alpha-Ketoglutartic Acid

 

Reaction 6: Oxidation, Decarboxylation, Thiol Ester Synthesis

This is the second oxidation reaction in which an alcohol is converted to a ketone. Two hydrogens and 2 electrons are transferred to NAD+ to NADH + H+.

A carbon group is lost as the second carbon dioxide in a decarboxylation reaction.

The remaining 4 carbon succinyl group is attached to the CoA through a thiol ester high energy bond.

This reaction is catalyzed by alpha-ketoglutarate dehydrogenase complex.

Succinyl CoA

Color Codes
C

H

N

O

P

S

Cl

F

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Remove carboxylic acid group, add CoA
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