Reaction 6: Oxidation, Decarboxylation, Thiol Ester Synthesis
This is the second oxidation reaction in which an alcohol
is converted to a ketone. Two hydrogens and 2 electrons are transferred
to NAD+ to NADH + H+.
A carbon group is lost as the second carbon dioxide in a decarboxylation
The remaining 4 carbon succinyl group is attached to the CoA
through a thiol ester high energy bond.
This reaction is catalyzed by alpha-ketoglutarate dehydrogenase