Coenzyme A

 

Initiating Step:

Before fatty acids can be oxidized, they must first undergo an initiating or priming step. Fatty acids in the cytoplasm must cross the mitachondrial membrane before the oxidations begin. Simple fatty acids are unable to cross this membrane unassisted.

The overall initiating step is the reaction of the fatty acid with coenzyme A in a thioester formation. This reaction requires energy and is therefore coupled with the hydrolysis of ATP to AMP.

Palmitic Acid 

Color Codes
C

H

N

O

P

S

Cl

F

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Remove H on CoA and OH on acid
  Reaction Changes / ball & stick
      

 

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    MEP / ball & stick     MEP / ball & stick
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